Influenza Pseudotyped Reporter Virus Particles

Influenza Components



Antibody neutralization
Serum screening
High-throughput assays


BSL-2 use 
Stable HA sequence 
Quantitative readout

Influenza RVP Product Offerings

For your pandemic and seasonal influenza research, we offer a variety of Influenza A and Influenza B strains. We currently offer strains from the following subtypes and lineages:

Virus Subtype or lineage
Influenza A H1N1
Influenza A H3N2
 Influenza A H5N1
 Influenza B Yamagata
 Influenza B Victoria

Need something you don’t see? We update our catalog regularly, and we can create custom RVPs to meet your needs.


Integral Molecular’s Influenza Reporter Virus Particles (RVPs) are replication-incompetent pseudotyped virus particles that enable safe (BSL-2), easy, and high-throughput viral infectivity and neutralization assays using standard detection instrumentation. The RVPs display hemagglutinin (HA) and neuraminidase (NA) proteins on a heterologous virus core and carry a modified genome that expresses a convenient optical reporter gene (GFP or luciferase).

Conventional hemagglutination and microneutralization assays require handling of live and sometimes highly pathogenic BSL-3 viruses that are subject to drift upon propagation. In contrast, Influenza RVPs are a phenotypically stable, safe, and ready-to-use reagent.

RVP Readouts: agglutination and infection

Agglutination and Neut, Influenza


A) Influenza RVPs containing HA and NA proteins agglutinated red blood cells upon incubation for 1 hour. B) Infection of HEK-293T cells with Influenza RVPs was inhibited by a neutralizing monoclonal antibody (Sino #68031-H011). A non-neutralizing control antibody did not inhibit infection.


Influenza Expertise

When you use Influenza Reporter Virus Particles, you gain access to our 20+ years of virology experience.

Integral Molecular is the industry leader in providing RVPs for applications including antibody R&D and serum screening for vaccine clinical trials. We also support basic virology research through collaborations and through our own peer-reviewed publications.

To see more of our publications, visit the Resources page