Membrane Proteome Array™

Modulation of immune cell subsets has proven a successful therapeutic approach for treating cancers — e.g. PD-(L)1 inhibitors. However, current attempts to identify new immunomodulatory proteins rely on homology-based approaches. In contrast, the Membrane Proteome Array is ideally suited to the discovery of new therapeutic targets as each protein is expressed in its native form on the surface of live human cells, enabling signaling assays to detect functional interactions. Using this platform, we were able to discover dozens of new immuno-modulatory proteins in a hypothesis free manner — generating a list of novel druggable targets along multiple therapeutic axes.